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KMID : 0603820130190010025
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Journal of Experimental & Biomedical Science
2013 Volume.19 No. 1 p.25 ~ p.31
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Construction of a Cell-Adhesive Nanofiber Substratum by Incorporating a Small Molecule
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Jung Dong-ju
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Abstract
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Electrospun nanofibers are being widely used as a substratum for mammalian cell culture owing to their structural similarity to collagen fibers found in extracellular matrices of mammalian cells and tissues. Especially, development of diverse synthetic polymers has expanded use of electrospun nanofibers for constructing cell culture substrata. Synthetic polymers have several benefits comparing to natural polymer for their structural consistency, low cost, and capability for blending with other polymers or small molecules to enhance their structural integrity or add biological functions. PMGI (polymethylglutarimide) is one of the synthetic polymers that produced a rigid nanofiber that enables incorporation of small molecules, peptides, and gold nanoparticles through co-electrospinning process, during which the materials are fixed without any chemical modifications in the PMGI nanofibers by maintaining their activities. Using the phenomenon of PMGI nanofiber, here I introduce a construction method of a nanofiber substratum having cell-affinity function towards a pluripotent stem cell by incorporating a small molecule in the PMGI nanofiber.
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KEYWORD
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PMGI (polymethylglutarimide), Electrospun nanofiber, Adhesamine, Pluripotent stem cell
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